http://gynecologycancer.org/new-cover-page daily 1.0 2016-06-22 http://gynecologycancer.org/about daily 0.75 2025-11-06 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457624926156-GZIDSUM1081H313N8W8F/image-asset.jpeg . Projected structure of green florescence protein (GFP) based on crystal structure. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1528287509218-RC5R23KTOA1GUCVPVYE5/cover.jpg . http://gynecologycancer.org/welcome daily 0.75 2016-01-28 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1451410844052-UTZVAR9O68U8YXUKKM4S/shihlab-hp.jpg HOME http://gynecologycancer.org/read-me daily 0.75 2025-12-12 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1455458690036-GQDHMBP0YEJQSO27TCIC/image-asset.jpeg . https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1468963489820-T5KWYXJ4EYEQXNGAVL4R/image-asset.jpeg . https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1458220017755-9X3IW2XUV18SRRC8GY3J/Telinde+program+banner.jpg . http://gynecologycancer.org/contact daily 0.75 2025-12-12 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1501682146505-01XA1A5DUSDBM9SC1FZ8/image-asset.jpeg Ovarian Cancer SPORE https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1453657666246-J6OVHWEGLFJ9BYIGJW6F/Figure+1.jpg Ovarian Cancer SPORE Figure 4. Barrier 1. The lack of effective tools for early detection of HGSC is largely because we did not know the precursor lesions of HGSC until recent research findings proposed a new paradigm- many HGSCs are derived from serous tubal intraepithelial carcinoma (STIC) in the fallopian tube, especially the fimbriated ends. STIC cells can then shed onto ovarian and peritoneal surfaces to become an “ovarian” carcinoma. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454919319602-Y7X3Z98SMDM058G5BH4U/image-asset.jpeg Ovarian Cancer SPORE Gross picture of an ovarian high-grade serous carcinoma involving small intestine. High-grade serous carcinoma is the most common and aggressive type of ovarian epithelial carcinoma. It is always diagnosed at advanced stage (like this case illustrated). The 5-year survival rate is less than 40%. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1458077363008-ND7TOV3VS24HYKNJOSIW/image-asset.jpeg Ovarian Cancer SPORE Fig. 7B. PD-1 positive T lymphocytes infiltrate a high-grade ovarian serous carcinoma. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1455183979389-WX05HX45OH3XZ376WJQT/image-asset.jpeg Ovarian Cancer SPORE Figure 5. After chemotherapy (carboplatin and paciltaxel), the majority of ovarian HGSC cells die, forming tumor necrosis. However, tumor cells that are refractory to chemotherapy survive and expand to form a recurrent tumor. It is the recurrent chemoresistant tumor cells that cause cancer-related morbidity and mortality. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1453753138815-D4FPMGM996DV74YNMECU/image-asset.jpeg Ovarian Cancer SPORE https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454110446237-V12LN2I6VSPROTZLRMWZ/image-asset.jpeg Ovarian Cancer SPORE Figure 2. Carcinogenesis of endometriosis-associated ovarian neoplasms. Ovarian endometrioma (depicted) is lined by a single layer of endometriotic epithelium. Repeated hemorrhage as occurs during menstruation creates a highly inflammatory microenvironment. Reactive oxygen species are produced through the Fenton's reaction in the presence of abundance ferrous iron. These free radicals are highly genotoxic and may damage DNA of epithelial cells, a prerequisite step leading to gene mutations. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454035808865-MMQ2OBDU9ES99Q76LUYI/image-asset.jpeg Ovarian Cancer SPORE Figure 3. The histologic features of an ovarian clear cell carcinoma (H&E, left panel). An identical PIK3CA somatic mutation is detected in both clear cell carcinoma and the adjacent endometriotic cyst epithelium, suggesting that endometriotic cyst epithelium is the precursor of clear cell carcinoma. http://gynecologycancer.org/home daily 0.75 2025-11-06 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1501682053041-57RRLMF8UX6AA3H34VKD/ovarian+cancer+graph+v4.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1458760765508-0D3DSEVA7VLNF5P2IEFJ/magnifier+mutation.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457144200748-KED5O8FM3VJFFL22E6KY/P3051825+mod-2.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457624707496-CSM603D8BPO6LSC6ZA3Y/IMG_1576.JPG Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1469737887143-0GXWLY76NZPMV8GCY7O0/Untitled-1.jpg Research concepts - Incipient cancer cells from a fallopian tube https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457487574093-S8NE650K1YWB2BO7JPUS/laminin+STIC.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1461881468633-B36W2WFSJI4KUVCMWTZ9/P4291937.JPG Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454679901042-LJOAWUV3F7EVTS1C9R7L/cancer+map.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454678620394-09UPPMPAZ8WV1BL8YPT6/SBT+gross.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1456701115126-NWI49BF04SMPASL00WFJ/centrosome.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1455255769043-A0TWKWR2WARZND4W1K2J/endometriosis.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457453966745-IEP9SNYTOENL57TNQ8W4/Shih+AACR+2015+ERON+final.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454842720608-IGKCYZPIT8V2KCBNFIZJ/cell+senescence.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454843310067-R63ACM0GPUF5KQE5FE2N/tubal+origin+cartoon.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1454893121654-HVF78X40JU2RXSCTLJH9/liquid+bx.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1460424758355-5ZDAPM8X8Z5P5PI8ICXR/USC.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1455302633202-IW8G8TGHZGL88TLYVRDM/gene+expression+heatmap.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1456759681512-OPEPC0R93MYUT8QTD0RG/ascities.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1460511504411-T2O14129EJUPRQEU5TBY/IF-2.jpg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1461631456338-GSN89D7VR20LL4TQ53T9/image-asset.jpeg Research concepts https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1459015358994-ORAQTNVG3OWLJEBO169P/image-asset.jpeg Research concepts http://gynecologycancer.org/new-page-2 daily 0.75 2017-04-24 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457627303882-OE7AOHWXB1UVH9BPSKX1/image-asset.jpeg . NAC1 knockdown impaired cytokinesis and resulted in polyploidy cells. https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1456674106003-6VJ6IBB3NR1Y84KVHIDK/image-asset.jpeg . A corner at the Gynecologic Pathology Laboratory (outside the cold room) https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1466954536162-DFNAT4C5DP8KDSZ81KJP/shihlab-hp.jpg . http://gynecologycancer.org/alumni daily 0.75 2019-06-10 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1457984493248-NA4IDII273OJ9HO28VU6/image-asset.jpeg Alumni http://gynecologycancer.org/origin-of-ovarian-cancer daily 0.75 2016-03-21 http://gynecologycancer.org/resource-sharing daily 0.75 2016-04-06 http://gynecologycancer.org/research-topics daily 0.75 2025-12-12 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1466615907222-IIWFWGU7OBQ5UEXKWC9L/image-asset.jpeg Research projects https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1466531354175-LOPAB1AMI1WHLRM4XFB7/image-asset.jpeg Research projects https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1467149103177-TW4PNV6LGFS11FDKJYTR/image-asset.jpeg Research projects https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1467589436479-7XH546D05ZO4DPFR6S18/image-asset.jpeg Research projects https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1466531591819-743UM63Y4DP6VPA9KRXM/image-asset.jpeg Research projects http://gynecologycancer.org/people daily 0.75 2025-11-06 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/1528556659504-IBY8TCUV6QLHEHRRMNNN/_JRC9158c.jpg People Lab members 2018 http://gynecologycancer.org/new-page daily 0.75 2025-11-07 https://images.squarespace-cdn.com/content/v1/56796e15df40f3876baee2e3/82c23ddc-1c9d-4110-8bfb-74a10afcab62/update+STICtoHGSC_v14_08.02.19.jpg Ovarian Precancer Atlas